Gender differences in the levels of bisphenol A metabolites in urine |
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Authors: | Kim Yong-Hak Kim Cheong-Sik Park Soyeon Han Soon Young Pyo Myoung-Yun Yang Mihi |
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Affiliation: | Department of Preventive Medicine, School of Medicine, Seoul-National University, 28 Yon-gun Dong, Chong-no Gu, Seoul 110-799, Republic of Korea. |
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Abstract: | The metabolism of bisphenol A (BPA), a suspected endocrine disruptor, should be considered for monitoring human exposure to BPA, because the conjugation with beta-D-glucuronide and sulfate reduces the estrogenic activity. In this study, BPA levels in 30 healthy Koreans (men, N=15, 42.6+/-2.4 years; women, N=15, 43.0+/-2.7 years) were analyzed from urine treated with/without beta-glucuronidase and/or sulfatase by an RP-HPLC with fluorescence detection. The total BPA concentrations including free BPA and the urinary conjugates were similar in men and women (2.82+/-0.73 and 2.76+/-0.54 ng ml(-1), respectively), but gender differences were found in the levels of urinary BPA conjugates. Men had significantly higher levels of BPA-glucuronide (2.34+/-0.85 ng ml(-1)) than women (1.00+/-0.34 ng ml(-1)), whereas women had higher levels of BPA-sulfate (1.20+/-0.32 ng ml(-1)) than men (0.49+/-0.27 ng ml(-1)). |
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Keywords: | Bisphenol A Endocrine disruptor β-Glucuronidase Sulfatase Urinary conjugates |
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