Biological activity of metal complexes. I. Interaction of pt(II), pd(II) and rh(I) complexes with E. coli strains and with mice LS fibroblasts in vitro. |
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| Authors: | M Aresta D Giordano A Ingrosso S Riccardi E Sinigaglia |
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| Affiliation: | 1. Istituto di Chimica Generale ed Inorganica, Università, Via Amendola 173, 70126 Bari Italy;2. Istituto di Patologia Generale, II Cattedra, Università, Piazza Giulio Cesare, 70124 Bari Italy |
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| Abstract: | The effects of a number of Pt(II, Pd(II) and Rh(I) complexes against cultures of Escherichia coli (strains B, H10178, uvra-, recA-) and cultures of mice LS Fibroblasts were tested. Most of the compounds showed higher cytotoxic activity than the cis-Pt(NH3)2Cl2, the compound at present on clinical trial as antittumour drug. A new model of active compound is proposed. |
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| Keywords: | DMSO dimethylsulphoxide |
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