Immunocytochemical localization of neurons containing the AMPA GluR2/3 subunit in the hamster visual cortex |
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Authors: | Ryoo Soo-Ryoon Ahn Chang-Hyun Lee Jae-Young Kang Youn-Sil Jeon Chang-Jin |
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Affiliation: | Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu 702-701, Korea. |
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Abstract: | AMPA glutamate receptors play a crucial role in brain functions such as synaptic plasticity and development. We have studied the chemo-architecture of the AMPA glutamate receptor subtype GluR2/3 in the hamster visual cortex by immunocytochemistry and compared it with the distribution of the calcium-binding proteins, calbindin D28K and calretinin. Anti-GluR2/3-immunoreactive (IR) neurons were predominantly located in layers II/III, V, and VI, and the majority of the labeled neurons were round or oval. However, many pyramidal cells in layer V were also labeled. Two-color immunofluorescence revealed that none of the GluR2/3-IR neurons contained calbindin D28 K or calretinin. Thus specific layers of neurons express the GluR2/3 subunit and these do not correlate with expression of calbindin D28K and calretinin. |
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