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A mitochondrial DNA variant 10398G>A in breast cancer among South Indians: An original study with meta-analysis |
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| Authors: | Amirtharaj Francis Singh Pooja Singh Rajender Periyasamy Govindaraj Nageswara Rao Tipirisetti Daminani Surekha Digumarthi Raghunatha Rao Lakshmi Rao Lingadakai Ramachandra Satti Vishnupriya K. Ramalingam Kapaettu Satyamoorthy Kumarasamy Thangaraj |
| Affiliation: | 1. CSIR-Centre for Cellular and Molecular Biology, Hyderabad, India;2. Endocrinology Division, CSIR-Central Drug Research Institute, Lucknow, India;3. Department of Pathology, Chhatrapati Sahuji Maharaj Medical University (CSMMU), Lucknow, India;4. Department of Biomedical Science, School of Basic Medical Sciences, Bharathidasan University, Tiruchirappalli, India;5. Department of Genetics, Osmania University, Hyderabad, India;6. Nizam''s Institute of Medical Sciences, Hyderabad, India;7. Department of Pathology, Kasturba Medical College, Manipal University, Manipal, India;8. Department of Surgery, Kasturba Medical College, Manipal University, Manipal, India;9. Department of Advanced Zoology and Biotechnology, Government Arts College, Chennai, India;10. Manipal Life Sciences Center, Manipal University, Manipal, India |
| Abstract: | The m.10398G > A polymorphism in the MT-ND3 gene has been linked to the manifestation of several neurodegenerative disorders and cancers. Several research groups have analyzed the association between m.10398G > A polymorphism and breast cancer; however, the results do not follow a consensus. We have studied this polymorphism in three Dravidian populations from South India. Analysis on 716 cases and 724 controls found no association between m.10398G > A polymorphism and breast cancer [OR = 0.916 (0.743–1.128); P = 0.409]. Menopausal stratification also revealed no significant association in either pre-menopausal or post-menopausal breast cancer groups. In addition, we undertook a meta-analysis on 16 study groups, comprising a total of 7202 cases and 7490 controls. The pooled odds ratio suggested no significant association of m.10398G > A substitution with breast cancer [OR = 1.016 (0.85–1.22); P = 0.86]. In conclusion, there is no evidence of association between m.10398G > A polymorphism and breast cancer risk among South Indian women. Meta-analysis suggested no overall correlation between this polymorphism and breast cancer risk. |
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