Type II Fp of human mitochondrial respiratory complex II and its role in adaptation to hypoxia and nutrition-deprived conditions |
| |
| Authors: | Chika Sakai Eriko Tomitsuka Makoto Miyagishi Shigeharu Harada Kiyoshi Kita |
| |
| Affiliation: | 1. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan;2. Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Ibaraki 305-8568, Japan;3. Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Kyoto 606-8585, Japan |
| |
| Abstract: | The flavoprotein (Fp) subunit of human mitochondrial succinate-ubiquinone reductase (SQR, complex II) has isoforms (type I, type II). Type II Fp is predominantly expressed in some cancer and fetal tissues and those tissues are often exposed to ischemia. The present study shows that complex II with type II Fp has lower optimal pH than complex II with type I Fp, and type II Fp mRNA expression was induced by ischemia. The result suggests complex II with type II Fp may function in cells with low mitochondrial matrix pH caused by ischemia and its function is related to cellular adaptation to ischemia. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
