Mitochondrial dysfunction and the inflammatory response |
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Authors: | María J López-Armada Romina R Riveiro-Naveira Carlos Vaamonde-García Marta N Valcárcel-Ares |
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Institution: | Aging and Inflammation Research Laboratory, Instituto de Investigación Biomédica A Coruña (INIBIC)-Complexo Hospitalario Universitario A Coruña (CHUAC)-SERGAS, Xubias 84, 15006, A Coruña, Spain |
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Abstract: | Inflammation has been linked to multiple degenerative and acute diseases as well as the aging process. Moreover, mitochondrial alterations play a central role in these processes. Mitochondria have an important role in pro-inflammatory signaling; similarly, pro-inflammatory mediators may also alter mitochondrial function. Both of these processes increase mitochondrial oxidative stress, promoting a vicious inflammatory cycle. Additionally, damage-associated molecular patterns derived from mitochondria could contribute to inflammasome formation and caspase-1 activation, while alterations in mitochondrial autophagy may cause inflammation. Strategies aimed at controlling excessive oxidative stress within mitochondria may represent both preventive and therapeutic interventions in inflammation. |
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