The role of RXR-alpha in retinoic acid-induced cleft palate as assessed with the RXR-alpha knockout mouse |
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| Authors: | Nugent P Sucov H M Pisano M M Greene R M |
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| Institution: | Department of Molecular, Cellular and Craniofacial Biology, University of Louisville School of Dentistry and University of Louisville Birth Defects Center, KY 40292, USA. pfnuge01@gwise.louisville.edu |
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| Abstract: | Treatment of pregnant mice with retinoic acid (RA) in mid-gestation produces cleft palate and limb defects in the fetuses. RXR-alpha has been previously shown to mediate the teratogenic effects of RA in the limb. In this study, we show that RXR-alpha is also involved in retinoid-induced palatal clefting. Treatment of RXR-alpha knockout mice with a teratogenic dose of RA on gestation day 11 or 12 induces cleft palate at a lower frequency than that seen in wild-type animals. |
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