中药补骨脂及鸦胆子对大鼠卡氏肺孢子虫肺炎的防治研究

目的探讨中药补骨脂及鸦胆子对大鼠卡氏肺孢子虫肺炎的防治效果。方法用地塞米松皮下注射建立大鼠卡氏肺孢子虫肺炎动物模型,用补骨脂、鸦胆子及两者合剂治疗实验鼠,观察其肺脑组织病理、肺脑组织和血清中MDA(丙二醛)、XOD(黄嘌呤氧化酶)、GSH(谷胱甘肽)等指标变化。结果补骨脂、鸦胆子及合剂治疗实验大鼠体重明显回升,与模型对照差异有显著性(P<005);各治疗组的包囊减少率均高于60%,合剂治疗组不优于各单独治疗组,鸦胆子及合剂治疗组清除氧自由基能力较强。结论鸦胆子及补骨脂对大鼠卡氏肺孢子虫肺炎具有一定疗效。

The therapeutic effect of brucea javanica and fructus psoraleae on Pneumocystis carinii pneumonia of rat model

Objective To study therapeutic effect of fructus psoraleae,brucea javanica and mixture on Pneumocstis carinii pneumonia(PCP) of immuosuppressed experimental rats.Methods PCP animal models were extabished by hypodermic injection of dexamethasone in rats.After using drogs,all rats were necropsied at the end of 8th week.The evaluation of drug efficacy was decided on the base of incrased of body weight,mean cyst number per field in lung print smear,XOD,MDA and GSH in the serum and the tissue of brain and lung.Results The increase of body weight treated with brucea javanica,fructus psoraleae and mixture were more than that of immunosuppressed rats control respectively.The reduce rates of cyst in the treated groups were more than 60%(the group of mixture was no better than the other two groups).The group of brucea javanica and mixture were good at getting rid of oxygen-derived free radicals.Conclusion The therapeutic effects of treatment of rat PCP with brucea javanica and fructus psoraleae were active.