航天飞行后心血管失调的外周效应器机制假说

作者及其同事曾用尾部悬吊大鼠模型模拟失重时的血液头向转移和重新分布变化,较系统地研究了模拟失重下心肌与动脉血管结构和功能的适应性改变。联系２０世纪９０年代空间研究与地面模拟研究最新进展,多们认为,除血量减少因素外,心血管系统的两个主要效应器－心肌和动脉血管平滑肌,在失重时发生的适应性结构和功能改变可能是导致航天飞行后心血管失调的重要原因之一。

Peripheral effector mechanism hypothesis on cardiovascular dysfunction after spaceflight

In the years of 1990's, we systematically studied the adaptational changes in structure and function of both the heart and the vessels during simulated weightlessness. In our serial work, the tail suspension rat model was used to simulate the microgravity induced cephalad shift and redistribution of blood. On the basis of the facts we observed and the more recent advances in space and ground based studies in 1990's, we put forward a hypothesis to offer a possible explanation for the frequent occurrence of postflight cardiovascular dysfunction. It states that, in addition to the factor of hypovolemia, the microgravity induced adaptational changes in the structure and function of the two main effectors of the cardiovascular system, i.e., the arterial smooth muscle and the cardiac muscle might be one of the most important mechanisms accounting for postflight cardiovascular dysfunction.