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A short synthesis of troglitazone: an antidiabetic drug for treating insulin resistance |
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| Authors: | Cossy J Menciu C Rakotoarisoa H Kahn P H Desmurs J R |
| Institution: | a Laboratoire de Chimie Organique, associé au CNRS, ESPCI, 10 rue Vauquelin 75231-, PARIS Cedex 05 —, France b Rhône-Poulenc Industrialisation, Centre de Recherche d'Ingénierie et de Technologie, 85 Avenue des Frères Perret, 69192 -, Saint-Fons Cedex —, France |
| Abstract: | Troglitazone was obtained in 5 steps from 4-bromo-1,1-dimethoxy-3-methylbut-2-ene with an overall yield of 7.5%. The formation of the chromane ring was achieved by condensing an unsaturated acetal with trimethylhydroquinone in the presence of bis(trifluoromethylsulfonyl)imide. |
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