Synthesis of Hsp90 dimerization modulators |
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Authors: | Chiosis Gabriela Aguirre Julia Nicchitta Christopher V |
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Affiliation: | Program in Molecular Pharmacology and Chemistry, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. chiosisg@mskcc.org |
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Abstract: | The synthesis and evaluation of several chemical modulators of heat shock protein 90 (Hsp90) dimerization is presented. These agents may represent useful tools to study the importance of N-terminal dimerization and also to determine subunit interface(s) in Hsp90. |
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