Novel oligodendrocyte transmembrane signaling systems |
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Authors: | Charissa A Dyer |
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Institution: | (1) Department of Biomedical Sciences, E. K. Shriver Center, 02254 Waltham, MA |
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Abstract: | Antibodies are increasingly being used as tools to study the function of cell surface markers. Several types of responses
may occur upon the selective binding of an antibody to an epitope on a receptor. Antibody binding may trigger signals that
are normally transduced by endogenous ligands. Moreover, antibody binding may activate normal signals in a manner that disrupts
a sequence of events that coordinates either differentiation, mitogenesis, or morphogenesis. Alternately, it is possible that
binding elicits either a modified signal or no signal. This article focuses on the cascade of events that occur following
specific antibody binding to myelin markers expressed by cultured murine oligodendrocytes. Binding of specific antibodies
to the oligodendrocyte membrane surface markers myelin/oligodendrocyte glycoprotein (MOG), myelin/oligodendrocyte specific
protein (MOSP), galactocerebroside (GalC), and sulfatide on cultured murine oligodendrocytes results in different effects
with regard to phospholipid turnover, Ca2+ influxes, and antibody:marker distribution. The consequence of each antibody-elicited cascade of events appears to be the
regulation of the cytoskeleton within the oligodendroglial membrane sheets. The antibody binding studies described in this
article demonstrate that these myelin surface markers are capable of transducing signals. Since endogenous ligands for these
myelin markers have yet to be identified, it is not known if these signals are normally transduced or are a modification of
normally transduced signals. |
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Keywords: | Antibody transmembrane signaling oligodendrocytes glycoproteins transmembrane proteins cytoskeleton calcium fluxes phospholipid turnover |
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