Osteopontin identified as colon cancer tumor progression marker |
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Authors: | Agrawal Deepak Chen Tingan Irby Rosalyn Quackenbush John Chambers Ann F Szabo Marianna Cantor Alan Coppola Domenico Yeatman Timothy J |
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Affiliation: | Department of Cell Biology, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA. |
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Abstract: | Identifying molecular markers for colon cancer is a top priority. Using a pooled sample approach with Affymetrix GeneChip technology, we assayed colon cancers derived from a series of clinical stages to identify molecular markers of potential prognostic value. Of 12000 genes assessed, osteopontin emerged as the leading candidate tumor progression marker. Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression. |
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