Commercially available histoplasmin sensitized latex particles in an agglutination test for histoplasmosis |
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| Authors: | Grace B Hill BS Charlotte C Campbell BS |
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| Institution: | (1) Veterans Administration Central Laboratory for Clinical Pathology and Research and Department of Bacteriology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C.;(2) Department of Bacteriology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. |
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| Abstract: | Summary A commercial preparation of histoplasmin sensitized latex particles was tested in an agglutination test with sera from 50 culturally confirmed cases of histoplasmosis in varying stages of the infection. The reactions were superior to those obtained with collodion agglutination and complement fixation tests in which the antigen histoplasmin was also used. The latex agglutination test with the commercially available antigen is easy to do, and can be done in any laboratory equipped to carry out agglutination tests with the common bacterial antigens. It warrants more extensive trial in the general hospital laboratory as a screening test for histoplasmosis, especially the primary, pulmonary type. |
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