Chromium in carbohydrate and lipid metabolism |
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Authors: | C Michele Davis J B Vincent |
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Institution: | (1) Department of Chemistry, University of Alabama, Tuscaloosa, AL 35487-0336, USA Tel.: +1-205-348-9203; Fax: +1-205-348-9104; e-mail: JVINCENT@ua1vm.ua.edu, VC |
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Abstract: | Since the discovery in the 1950s that mammals have a nutritional requirement for chromium, the biological function of chromium
has been sought. Candidates for the naturally-occurring biologically active form of chromium have been proposed, but, until
recently, all have been shown to be artifacts. Recent studies examining the properties of the oligopeptide low-molecular-weight
chromium-binding substance (LMWCr) suggest that this material may have a role in carbohydrate and lipid metabolism as part
of a novel insulin-signaling amplification mechanism and may have implications in the treatment of diabetes and related conditions.
Received: 24 March 1997 / Accepted: 9 September 1997 |
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Keywords: | Chromium Insulin receptor Low-molecular-weight chromium-binding substance Diabetes Glucose tolerance factor |
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