Adiposity and Diabetes Risk in Adults with Prediabetes: Heterogeneity of Findings Depending on Age and Anthropometric Measure |
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| Authors: | Carolina Giráldez‐García Josep Franch‐Nadal F Javier Sangrós Antonio Ruiz Francisco Carramiñana Albert Goday Mercè Villaró F Javier García‐Soidán Rosario Serrano Enrique Regidor the PREDAPS Study Group |
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| Institution: | 1. redGDPS Foundation, Madrid, Spain;2. Infanta Elena University Hospital, Madrid, Spain;3. Barcelona City Research Support Unit/University Institute for Research in Primary Care Jordi Gol, Barcelona, Spain;4. Biomedical Research Networking Centre Consortium on Diabetes and Associated Metabolic Disorders, Madrid, Spain;5. Department of Medicine, University of Barcelona, Barcelona, Spain;6. Torrero‐La Paz Health Center, Zaragoza, Spain;7. Pinto Health Center, Madrid, Spain;8. San Roque Health Center, Badajoz, Spain;9. Department of Endocrinology, Hospital del Mar, Barcelona, Spain;10. Terrassa Sud Primary Care Center, Barcelona, Spain;11. Porri?o Health Center, Pontevedra, Spain;12. Martín de Vargas Health Center, Madrid, Spain;13. Biomedical Research Networking Centre Consortium on Public Health and Epidemiology, Madrid, Spain;14. Department of Preventive Medicine, Public Health and History of Science, Complutense University of Madrid, Madrid, Spain;15. Institute of Health Research in the Hospital Clínico San Carlos, Madrid, Spain |
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| Abstract: | Objective The study aimed to evaluate the effect of age on diabetes incidence by general and central adiposity after 3‐year follow‐up in adults with prediabetes. Methods Data were taken from a cohort of 1,184 subjects with prediabetes included in The Cohort Study in Primary Health Care on the Evolution of Patients with Prediabetes (PREDAPS). General adiposity was defined using body mass index (BMI), and central adiposity was defined with waist circumference and waist to height ratio. Data were analyzed by age groups 30 to 59 and 60 to 74 years. The association between adiposity and diabetes incidence was assessed using hazard ratios (HR). Results Adjusting for sociodemographic characteristics, lifestyles, and metabolic parameters, diabetes HR for central adiposity based on the waist circumference clinical cutoff were 2.14 (1.12‐4.09) and 1.48 (0.80‐2.74) for people aged 30 to 59 and 60 to 74 years, respectively. In the model additionally adjusted for BMI, diabetes HR were 2.65 (1.24‐5.65) and 1.33 (0.68‐2.59), respectively. The use of a 1‐SD increase rather than cutoff points did not alter this pattern. Similar findings were observed with central adiposity based on waist to height ratio. Conclusions The association of central adiposity with type 2 diabetes incidence was lower for people in the older age group than for those in the younger age group. |
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