| 吗啡对福尔马林引起大鼠海马内IL-2RβmRNA表达的影响 |
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| 作者姓名： | Wu X Li HD Li XC Ruan HZ Wang J |
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| 作者单位： | 第三军医大学生理教研室,重庆,400038 |
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| 摘 要： | 本实验采用原位杂交法观察足底注射福尔马林（Ｆｏｒ）痛敏对海马内白细胞介素２受体βｍＲＮＡ（ＩＬ－２ＲβｍＲＮＡ）生成的影响及其与吗啡、促肾上腺皮质激素（ＡＣＴＨ）的关系。结果表明：正常大鼠海马有ＩＬ－２ＲβｍＲＮＡ表达,集中分布于ＣＡ１－ＣＡ４区神经元、齿状回颗粒细胞。足底注射Ｆｏｒ后６ｈ双侧海马ＩＬ－２ＲβｍＲＮＡ表达均增加（Ｐ〈０．０５）,１２ｈ达高峰,２４ｈ仍高于正常。在６ｈ时,腹腔注射吗啡
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| 关 键 词： | 海马 吗啡 ACTH 原位杂交 IL－2RβmRNA |
| 修稿时间： | 1997年9月22日 |
Effects of morphine on the formalin induced IL-2R beta mRNA expression of rat hippocampus |
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| Wu X,Li HD,Li XC,Ruan HZ,Wang J.Effects of morphine on the formalin induced IL-2R beta mRNA expression of rat hippocampus[J].Acta Physiologica Sinica,1998,50(5):591-594. |
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| Authors: | Wu X Li H D Li X C Ruan H Z Wang J |
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| Institution: | Department of Phisiology, Third Military Medical University, Chongqing 400038. |
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| Abstract: | Using method of in situ hybridization, the effects of subcutaneous injection (s.c.) of formalin (For) into one hindpaw (hyperalgesia) on IL-2R beta mRNA expression in hippocampus (Hip) were studied. In addition, the effects of coadministration of morphine (i.p.) or ACTH (i.p.) with For (s.c.) were studied also. It was found that IL-2R beta mRNA was present in normal rat's Hip, intensely in granular cells of dentate gyrus and CA1-CA4 neurons. Subcutaneous injection of For increased IL-2R beta mRNA from 6 h to at least 24 h, reaching a peak at 12 h. Coadministration with morphine enhanced the effects of For on IL-2R beta mRNA expression, but no significant change was found with coadministration of ACTH. The above results suggest that IL-2R might be involved in pain modulation. |
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