Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney |
| |
Authors: | Cunningham Patrick N Dyanov Hristem M Park Pierce Wang Jun Newell Kenneth A Quigg Richard J |
| |
Institution: | Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA. pcunning@medicine.bsd.uchicago.edu |
| |
Abstract: | Bacterial endotoxin (LPS) is responsible for much of the widespread inflammatory response seen in sepsis, a condition often accompanied by acute renal failure (ARF). In this work we report that mice deficient in TNFR1 (TNFR1(-/-)) were resistant to LPS-induced renal failure. Compared with TNFR1(+/+) controls, TNFR1(-/-) mice had less apoptosis in renal cells and fewer neutrophils infiltrating the kidney following LPS administration, supporting these as mediators of ARF. TNFR1(+/+) kidneys transplanted into TNFR1(-/-) mice sustained severe ARF after LPS injection, which was not the case with TNFR1(-/-) kidneys transplanted into TNFR1(+/+) mice. Therefore, TNF is a key mediator of LPS-induced ARF, acting through its receptor TNFR1 in the kidney. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|