An experimental model for selective inhibition of proliferating cells by chemotherapeutic agents |
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| Authors: | P M Naha |
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| Affiliation: | 1. School of Materials and Chemistry, Institute of Bismuth Science, Shanghai Collaborative Innovation Center of Energy Therapy for Tumors, University of Shanghai for Science and Technology, Shanghai 200093, China;2. Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital & Shanghai Institute of Ultrasound in Medicine, Shanghai 200233, China;3. Institute of Photochemistry and Photofunctional Materials (IPPM), University of Shanghai for Science and Technology, Shanghai 200093, China |
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| Abstract: | Conditionally transformable cells of primate origin in which 'untransformed' and 'transformed' cells derived from the same source grow in culture, has been used as an experimental system for testing selective inhibition of proliferating cells by chemotherapeutic agents. The cytotoxic agents Adriamycin and Mitomycin C fail to recognise "tumour cells" in a heterogenous population and thus differ from the non-toxic and non-carcinogenic agent L-canavanine. |
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