Gene regulation by histone H1: new links to DNA methylation |
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| Authors: | Rupp Ralph A W Becker Peter B |
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| Affiliation: | Adolf-Butenandt-Institut, Molekularbiologie, Schillerstr. 44 . 80336 München, Germany. |
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| Abstract: | Linker histones of the H1 family are among the most abundant components of chromatin. In this issue of Cell, the effect of H1 downregulation on gene expression is examined. Although a 50% reduction of histone H1 levels in embryonic stem cells affects chromatin structure globally, the expression of very few genes is altered. Intriguingly, this study reveals a new link between H1 and DNA methylation. |
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