1. Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan;2. Niigata University School of Medicine, Niigata, Japan
Abstract:
Adipocytes from streptozotocin-diabetic rats are approximately 50-times more sensitive to the lipolytic action of glucagon. This change is only perceived in the presence of a small quantity of adenosine deaminase which itself has little effect on basal lipolysis. Insulin treatment restores glucagon sensitivity to normal.