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Streptozotocin diabetes results in increased responsiveness of adipocyte lipolysis to glucagon |
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| Authors: | K Chatzipanteli D Saggerson |
| Affiliation: | 1. Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan;2. Niigata University School of Medicine, Niigata, Japan |
| Abstract: | Adipocytes from streptozotocin-diabetic rats are approximately 50-times more sensitive to the lipolytic action of glucagon. This change is only perceived in the presence of a small quantity of adenosine deaminase which itself has little effect on basal lipolysis. Insulin treatment restores glucagon sensitivity to normal. |
| Keywords: | C4b-binding protein Active fragment Limited proteolysis Subunit chain structure C4bp C4b-binding protein SDS-PAGE sodium dodecyl sulfate polyacrylamide gel electrophoresis DFP diisopropyl fluorophosphate PTH phenylthiohydantoin HPLC high-performance liquid chromatography DTT dithiothreitol |
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