Inhibitor of the DNA-dependent DNA Polymerase of Some RNA Tumour Viruses in Feline Sera |
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| Authors: | PRADIP ROY-BURMAN BIJAY K PAL MURRAY B GARDNER |
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| Institution: | 1.Departments of Pathology and Biochemistry,University of Southern California, School of Medicine,Los Angeles |
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| Abstract: | AN inhibitor of the RNA-dependent DNA polymerases1,2 of mammalian C-type viruses was found in sera from rats bearing transplantable tumours, induced by murine C-type RNA tumour viruses3,4. Partially purified polymerases of murine leukaemia virus3 and feline leukaemia virus (FeLV)4 were shown to be antigenic in rabbits and a rat, respectively. We have detected an inhibitor of the DNA-dependent DNA polymerase5,6 of feline and murine C-type viruses in the sera of cats inoculated in utero and/or postnatally with the Gardner-Arnstein strain of feline sarcoma virus (FSV)7 and in the sera of cats bearing spontaneous sarcomas, lymphomas or carcinomas. |
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