Development of highly selective fluorescent ferrocenyl-iminopyridine chemosensor for biologically relevant Fe3+ |
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Authors: | Himani Sharma Vaishali Singh Arpna Tamrakar Kamlesh Kumar Nigam Mrituanjay D Pandey Kamal Kant Tiwari Rampal Pandey |
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Institution: | 1. Department of Chemistry, National Institute of Technology Uttarakhand, Srinagar, Uttarakhand, India;2. Department of Chemistry, Institute of Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India |
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Abstract: | Design, synthesis, characterization, and ion detection studies of two ferrocene-appended Schiff bases namely N-(2-ferrocenylamino]ethyl)-5-nitropyridin-2-amine ( 1 ) and ferrocenylamino-1H-imidazole-4-carboxamide ( 2 ) been reported. Both the chemosensors have been thoroughly characterized using Fourier transfer infrared, 1H and 13C nuclear magnetic resonance, high resolution mass spectrometry, and ultraviolet/visible (UV/visible) and fluorescence spectral techniques. Probes 1 and 2 were designed with the aim of appending the ferrocenyl group with pyridine ring having an amine substitution (for 1 ) and imidazole ring with an amide substitution (for 2 ). Interaction of these probes with a series of cations and anions was examined through UV/vis and fluorescence spectral techniques. Probe 2 exhibited an insignificant response towards anions and loss of selectivity for cations, whereas 1 displayed highly selective detection towards biologically important Fe3+ in 2:1 (probe:cation) stoichiometry. Notably, none of the cations and anions could interfere the selectivity of Fe3+ ensured by 1 in aqueous medium. The limit of detection for Fe3+ detection using 1 was determined to be 0.2 ppm. The results strongly suggest that 1 could find promising future application as a chemosensor for Fe3+ in biological systems for quantification and qualitative analysis. |
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Keywords: | ferrocene fluorescence iron (III) Schiff base sensing UV/visible |
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