| Institution: | 1. Department of Chemistry, Acharya Nagarjuna University, NNagar, Guntur, 522510, AP- India
Department of Chemistry, Government Degree college, Rajhamundry, 533524, AP- India;2. Department of Chemistry, Acharya Nagarjuna University, NNagar, Guntur, 522510, AP- India;3. Department of Pharmaceutical Chemistry and Phytochemistry, Nirmala College of Pharmacy, Atmakur, Mangalagiri, Guntur, 522302, AP- India;4. Department of Pharmaceutical chemistry, College of Pharmacy, King Saud University, PO Box.2457, Riyadh, 11451 Saudi Arabia;5. Department of Drug Science & Technology, University of Turin, 10124 Turin, Italy |
| Abstract: | An efficient 1,4-dihydropyridine synthesis under mild conditions has been developed. Numerous substrates were tested, with yields of 1,4-dihydropridines ranging from good to excellent and a wide range of functional group tolerance. A549, HT-29, and HepG2 cancer cells were used to investigate the anticancer efficacy of each of the produced compounds. Additionally, in-silico docking studies were conducted to understand the structure-based features of the anticancer mechanism with the cancer medication target of Adenosine A2A receptor as well as the molecular level interactions of the compounds. |
