Secretor state and renal scarring in girls with recurrent pyelonephritis |
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Authors: | H. Lomberg,M. Hellströ m,U. Jodal,C. Svanborg Eden |
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Affiliation: | Department of Clinical Immunology, University of Göteborg, Göteborg, Sweden;Department of Pediatric Radiology, University of Göteborg, Göteborg, Sweden;Department of Pediatrics, East Hospital, University of Göteborg, Göteborg, Sweden |
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Abstract: | Abstract The non-secretor phenotype was significantly associated with the occurrence of renal scarring among patients with recurrent pyelonephritis. Girls ( n = 77) with recurrent pyelonephritis were followed from the first known episode of infection for up to twelve years with repeated radiological investigations. They were divided into two categories: those with renal scars ( n = 35) and those who did not develop scars ( n = 42). There was a significant over-representation of non-secretors among the patients with scarring, (14/35, 40%) compared to the healthy controls (21.8%, P < 0.05). The frequency of non-secretors among the girls who did not develop scars in spite of repeated episodes of acute pyelonephritis was not significantly different from the healthy controls (9/42, 21%, n.s.). This study provides a basis for analysis of the influence of secretor state on host-parasite interaction in the urinary tract. |
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Keywords: | Secretor status Pyelonephritis Renal scarring Blood group antigens |
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