Synthesis and pharmacological activity of betulin dinicotinate |
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| Authors: | Flekhter O B Karachurina L T Nigmatullina L R Sapozhnikova T A Baltina L A Zarudiĭ F S Galin F Z Spirikhin L V Tolstikov G A Pliasunova O A |
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| Affiliation: | Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054 Russia. obf@anrb.ru |
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| Abstract: | The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3,28-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, untiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2002, vol. 28, no. 6; see also http://www.maik.ru. |
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