| 滑膜细胞在骨关节炎中的研究进展 |
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| 引用本文： | 叶小康,白自然,金敏丽,尹春来,李霞. 滑膜细胞在骨关节炎中的研究进展[J]. 生物化学与生物物理进展, 2021, 48(11): 1282-1289 |
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| 作者姓名： | 叶小康 白自然 金敏丽 尹春来 李霞 |
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| 作者单位： | 大连医科大学基础医学院,大连 116044,大连医科大学基础医学院,大连 116044,大连医科大学基础医学院,大连 116044,大连医科大学基础医学院,大连 116044,大连医科大学基础医学院,大连 116044 |
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| 基金项目： | 国家自然科学基金（82071834,81671606）、辽宁省特聘教授 （2018-2020）、大连人体稳态微生物学与疾病免疫学重点实验室资 助项目. |
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| 摘 要： | 骨关节炎(osteoarthritis,OA)作为最常见的退行性关节疾病,其主要临床特点是软骨的破坏降解,进而导致关节功能丧失,严重影响患者的生活质量.越来越多的证据表明,除了软骨组织,OA的病理改变还涉及滑膜、骨以及软骨下骨在内的多个组织系统.其中,滑膜作为组织系统的重要组成部分,其病变在OA中的作用日益突出.滑膜细...
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| 关 键 词： | 骨关节炎 滑膜巨噬细胞 滑膜成纤维细胞 |
| 收稿时间： | 2021-01-11 |
| 修稿时间： | 2021-04-15 |
Research Progress of Synovial Cells in Osteoarthritis |
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| YE Xiao-Kang,BAI Zi-Ran,JIN Min-Li,YIN Chun-Lai and LI Xia. Research Progress of Synovial Cells in Osteoarthritis[J]. Progress In Biochemistry and Biophysics, 2021, 48(11): 1282-1289 |
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| Authors: | YE Xiao-Kang BAI Zi-Ran JIN Min-Li YIN Chun-Lai LI Xia |
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| Affiliation: | College of Basic Medical Science, Dalian Medical University, Dalian 116044, China,College of Basic Medical Science, Dalian Medical University, Dalian 116044, China,College of Basic Medical Science, Dalian Medical University, Dalian 116044, China,College of Basic Medical Science, Dalian Medical University, Dalian 116044, China,College of Basic Medical Science, Dalian Medical University, Dalian 116044, China |
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| Abstract: | Osteoarthritis (OA), as the most common degenerative joint disease, is mainly characterized by destruction and degradation of cartilage, which leads to joint function loss and seriously affects the quality of life of patients. More and more evidences show that in addition to cartilage tissue, the pathological changes of OA involve other tissue system including synovium, bone and subchondral bone. Among that, synovium, an important part of the tissue system, plays an increasingly prominent role in OA. Synovial cells are classified into type A synovial macrophage (SM) and type B synovial fibroblast (FLS), which play different but closely related roles in OA. This article reviews the role of different types of synovial cells in OA, and provides scientific theoretical basis for further understanding the pathogenesis and treatment of OA. |
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| Keywords: | osteoarthritis synovial macrophage fibroblast-like synoviocyte |
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