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Synthesis of N,N'-disubstituted 3-aminobenzo[c] and [d]azepin-2-ones as potent and specific farnesyl transferase inhibitors |
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| Authors: | Le Diguarher Thierry Ortuno Jean-Claude Shanks David Guilbaud Nicolas Pierré Alain Raimbaud Eric Fauchère Jean-Luc Hickman John A Tucker Gordon C Casara Patrick J |
| Affiliation: | Department of Medicinal Chemistry, Institut de Recherches Servier, 125 chemin de Ronde, 78290 Croissy sur Seine, France. |
| Abstract: | A structure-activity study was performed by synthesis on N,N'-disubstitution of 3-aminobenzo[c] and [d]azepin-2-one 2 and 3 to afford potent and specific farnesyl transferase inhibitors with low nM enzymatic and cellular activities. |
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