Junction-forming aquaporins |
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| Authors: | Engel Andreas Fujiyoshi Yoshinori Gonen Tamir Walz Thomas |
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| Institution: | Maurice E. Mueller Institute, University of Basel, Biozentrum, Klingelberstrasse 70, CH-4056 Basel, Switzerland. |
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| Abstract: | Aquaporins (AQPs) are a family of ubiquitous membrane channels that conduct water and solutes across membranes. This review focuses on AQP0 and AQP4, which in addition to forming water channels also appear to play a role in cell adhesion. We discuss the recently determined structures of the membrane junctions mediated by these two AQPs, the mechanisms that regulate junction formation, and evidence that supports a role for AQP0 and AQP4 in cell adhesion. |
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