Molecular evolution of Cide family proteins: Novel domain formation in early vertebrates and the subsequent divergence |
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| Authors: | Congyang Wu Yinxin Zhang Zhirong Sun Peng Li |
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| Affiliation: | (1) Protein science laboratory of Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, 100084 Beijing, China;(2) MOE Key Laboratory of Bioinformatics, State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, 100084 Beijing, China |
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| Abstract: | Background Cide family proteins including Cidea, Cideb and Cidec/Fsp27, contain an N-terminal CIDE-N domain that shares sequence similarity to the N-terminal CAD domain (NCD) of DNA fragmentation factors Dffa/Dff45/ICAD and Dffb/Dff40/CAD, and a unique C-terminal CIDE-C domain. We have previously shown that Cide proteins are newly emerged regulators closely associated with the development of metabolic diseases such as obesity, diabetes and liver steatosis. They modulate many metabolic processes such as lipolysis, thermogenesis and TAG storage in brown adipose tissue (BAT) and white adipose tissue (WAT), as well as fatty acid oxidation and lipogenesis in the liver. |
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