Inhibition of cytokinesis by wiskostatin does not rely on N-WASP/Arp2/3 complex pathway |
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Authors: | Guillaume Bompard Gabriel Rabeharivelo Nathalie Morin |
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Institution: | 1.CRBM, CNRS UMR 5237, Université Montpellier I et II,Montpellier Cedex 5,France |
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Abstract: | Background Cytokinesis is the final step of cell division taking place at the end of mitosis during which the cytoplasmic content and
replicated chromosomes of a cell are equally partitioned between the two daughter cells. This process is achieved by the formation
and the ingression of an actomyosin contractile ring under the control of equatorial microtubules. The mechanisms of contractile
ring formation are not fully understood but involve recruitment of preexisting actin filaments and de novo actin polymerisation. |
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