Pharmacokinetics of cephalexin in sea bream, Sparus aurata (L.), after a single intraperitoneal injection |
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| Authors: | P Katharios J Iliopoulou-Georgudaki S Antimisiaris T Verri P Toma R Acierno M Maffia |
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| Institution: | Department of Biology, Unit of Pollution and Ecotoxicology, University of Patras, Rio, Greece;;Department of Pharmacology, Univeristy of Patras, Rio, Greece;;Laboratory of General Physiology, Department of Biological and Environmental Sciences and Technologies, University of Lecce, Lecce, Italy |
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| Abstract: | The pharmacokinetic properties of cephalexin were studied in sea bream (mean weight 77 g), Sparus aurata (L.) after a single intraperitoneal injection (200 mg kg?1). Pharmacokinetic analysis of the serum concentrations vs time points obtained was performed using non‐compartmental analysis and a compartmental pharmacokinetic model approach. In the latter case, a two‐compartment open model with a lag time gave the best fitting. The maximum peak serum concentration was 5.018 mg ml?1 kg?1 1 h post‐treatment. The area under the curve (AUC) cephalexin was 17.394 mg·h kg?1 and the elimination half‐life of 1.83 h. |
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