beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action |
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| Authors: | Xiang Jason Ipek Manus Suri Vipin Tam May Xing Yuzhe Huang Nelson Zhang Yanling Tobin James Mansour Tarek S McKew John |
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| Affiliation: | Chemical and Screening Sciences, Wyeth Research, 200 Cambridge Park Drive, MA 02140, USA. jxiang@wyeth.com |
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| Abstract: | The design, synthesis, and biological evaluation of beta-keto sulfones as 11beta-HSD1 inhibitors and the mechanism of inhibition are described here. This class of compounds is not active against 11beta-HSD2 and therefore may have therapeutic potential for metabolic syndrome and type 2 diabetes. |
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