Wingless mutation inDrosophila melanogaster |
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Authors: | S. G. Bhat P. Babu |
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Affiliation: | (1) Molecular Biology Unit, Tata Institute of Fundamental Research, 400 005 Bombay, India |
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Abstract: | A temperature sensitive lethal allele of thewingless locus ofDrosophila melanogaster together with previously studied lethal and viable alleles in this locus, has been used to study some properties of this locus. These studies show the existence of two lethal phases for thewingless lesion; one during embryogenesis and another during pupation. By growing embryos with temperature sensitivewingless lesion at the permissive temperature and letting the larvae develop at non-permissive temperature, a large-scale cell death and subsequent regeneration were seen to occur in the mutant wing discs. This cell death followed by regeneration alters the normal developmental potential of the wing disc. Disc transplantation experiments show that these discs are incapable of differentiating into wing blade structures. |
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Keywords: | Drosophila wingless temperature-sensitive disc transplantation |
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