Heterogenous populations of cytotoxic cells in the peritoneal cavity of BALB/c mice immunized with allogeneic EL4 leukemia cells |
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| Authors: | J Zighelboim B Bonavida J L Fahey |
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| Institution: | Department of Microbiology and Immunology, University of California at Los Angeles School of Medicine, Los Angeles, California, U.S.A. |
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| Abstract: | Adherent cells, presumably macrophages, obtained from the peritoneal cavity shortly after rejection of the allogeneic leukemia EL4, produced effective cell-mediated cytotoxicity (CMC) in vitro. These cytotoxic cells were sensitive to anti-macrophage serum and resistant to anti-thymocyte serum and 10,000 roentgen irradiation. In contrast, a second population of specifically cytotoxic cells were nonadherent, sensitive to x-rays and anti-thymocyte serum, but not to anti-macrophage serum.The two cell populations had a cooperative cytotoxic effect in vitro against allogeneic tumor cells. |
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| Keywords: | CMC cell-mediated cytotoxicity PEC peritoneal exudate cells MEM minimum essential media SRBC sheep red blood cells EA erythrocytes sensitized with antibody FCS foetal calf serum NRS normal rabbit serum |
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