Nucleoside analogues exerting antiviral activity through a non-nucleoside mechanism |
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Authors: | De Clercq Erik |
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Institution: | Rega Institute for Medical Research, Leuven, Belgium. erik.declercq@rega.kuleuven.ac.be |
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Abstract: | In analogy with maribavir 1-(beta-L-ribofuranosyl)-isopropylamino-5,6-dichlorobenzimidazole], a nucleoside analogue that acts against human cytomegalovirus (HCMV) by a non-nucleoside mechanism, here I present three other examples of classes of nucleoside analogues (i.e. bicyclic furo2,3-d]pyrimidine as well as HEPT and TSAO derivatives) that act against either HCMV or human immunodeficiency virus (HIV) through a non-nucleoside mode of action. |
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