Actin machinery: pushing the envelope |
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| Authors: | Borisy G G Svitkina T M |
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| Affiliation: | Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706, USA. ggborisy@facstaff.wisc.edu |
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| Abstract: | The reconstitution of microbial rocketing motility in vitro with purified proteins has recently established definitively that no myosin motor is required for protrusion. Instead, actin polymerization, in conjunction with a small number of proteins, is sufficient. A dendritic pattern of nucleation controlled by the Arp2/3 complex provides an efficient pushing force for lamellipodial motility. |
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