Modulation of nitric oxide (NO) biosynthesis in lactobacilli |
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| Authors: | D. R. Yarullina O. A. Smolentseva O. N. Ilinskaya |
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| Affiliation: | (1) Toyama Institute for Cardiovascular Pharmacology Research, 7-13, 1-Chome, Azuchi-machi, Chuo-ku, Osaka, Japan;(2) Department of Pharmacology, Shiga University of Medical Science, Seta, Ohtsu, Japan |
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| Abstract: | We characterized effects of nitric oxide synthase (NOS) substrate L-arginine and classical inhibitors of mammalian NOS on nitric oxide (NO) biosynthesis in probiotic bacteria Lactobacillus plantarum 8P-A3. NO-synthase origin of nitric oxide detected by fluorescent NO indicator 1,2-diaminoanthraquinone (DAA) was confirmed by induction of NO production by exogenous L-arginine. None of the used inhibitors of three isoforms of mammalian NOSs (L-NAME, L-NIL, nNOS inhibitor I) showed significant inhibitory effect of lactobacillar NO-synthase activity. |
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