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Syntheses and structural studies of platinum(II) complexes of O-methylselenomethionine and related ligands |
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| Authors: | Michael Carland Teresa Rede Vincent Murray W David McFadyen |
| Institution: | a School of Chemistry, The University of Melbourne, Melbourne, Vic. 3010, Australia b School of Biochemistry and Molecular Genetics, University of New South Wales, Sydney, NSW 2052, Australia c Auckland Cancer Society Research Centre, Faculty of Medicine and Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand |
| Abstract: | The complexes dichloro2-(phenylselanyl)ethanamine]platinum(II), dichloro2-(benzylselanyl)ethanamine]platinum(II) and dichloro(O-methylselenomethionine)platinum(II) have been prepared and the structure of dichloro(O-methylselenomethionine)platinum(II) has been determined by single crystal X-ray diffraction. The Pt(II) is in a square planar environment and is coordinated by two cis chloride ligands and a chelating O-methylselenomethionine ligand. The cytotoxicities of the compounds have been assessed in the human cell lines HeLa and K562 and they are at least threefold less toxic than cisplatin in both cell lines. |
| Keywords: | Selenium-nitrogen chelates O-Methylselenomethionine Platinum(II) complexes Synthesis Crystal structure |
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