Cobalt(II) complexes of the antibiotic sulfadiazine, the X-ray single crystal structure of [Co(C10H9N4O2S)2(CH3OH)2] |
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| Authors: | Peter A Ajibade Paul O’Brien James Raftery |
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| Institution: | a University of Zululand, Department of Chemistry, Faculty of Science and Agriculture, Kwadlangezwa, Kwazu-Natal 3886, South Africa
b University of Manchester, Department of Chemistry, UK |
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| Abstract: | Cobalt(II) complexes of sulfadiazine formulated as Co(C10H9N4O2S)2(CH3OH)2] and Co(C10H9N4S)2(H2O)2] have been synthesized and characterized by elemental analysis, infrared and UV-Vis spectroscopy and magnetic susceptibility measurements. The crystal structures of the complex Co(C10H9N4O2S)2(CH3OH)2] and of free sulfadiazine are also reported. The cobalt complex and the sulfadiazine ligand both crystallize in the monoclinic space group, P21/c, with sulfadiazine acting as a bidentate ligand. Cobalt is coordinated to two-sulfonamide nitrogen and the pyrimidine nitrogen of the sulfadiazine. Two molecules of methanol complete the octahedral geometry around the cobalt, with interligand hydrogen bonding between methanol and sulfadiazine. Infrared spectroscopy confirmed the presence of water molecule in the coordination sphere of Co(C10H9N4S)2(H2O)2]. The electronic spectra and magnetic moments of both complexes were similar, indicating that both complexes have similar structure. |
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| Keywords: | Cobalt complexes Sulfadiazine Crystal structure Malaria Sulfanilamide Antibiotics |
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