Costimulation of Naive CD8+ Lymphocytes Induces CD4 Expression and Allows Human Immunodeficiency Virus Type 1 Infection |
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| Authors: | Scott G. Kitchen Yael D. Korin Michael D. Roth Alan Landay Jerome A. Zack |
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| Affiliation: | Division of Hematology-Oncology1. and Division of Pulmonary & Critical Care,3. Department of Medicine, Department of Pathology & Laboratory Medicine,2. and Department of Microbiology & Molecular Genetics,5. UCLA School of Medicine, Los Angeles, California 90095, and Department of Immunology & Microbiology, Rush Presbyterian-St. Luke’s Medical Center, Chicago, Illinois 606124. |
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| Abstract: | Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD4. Costimulation of CD8+/CD4− T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells induced expression of CD4 and rendered these CD8 cells susceptible to HIV-1 infection. Naive CD45RA+ cells responded with greater expression of CD4 than did CD45RO+ cells. CD8+ lymphocytes derived from fetal or newborn sources exhibited a greater tendency to express CD4, consistent with their naive states. This mechanism of infection suggests HIV-induced perturbation of the CD8 arm of the immune response and could explain the generally rapid disease progression seen in HIV-infected children. |
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