The Level of Isoprostanes as a Non-invasive Marker for <Emphasis Type="Italic">in vivo</Emphasis> Lipid Peroxidation in Secondary Progressive Multiple Sclerosis |
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Authors: | El?bieta Miller Ma?gorzata Mrowicka Joanna Saluk-Juszczak Majsterek Ireneusz |
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Institution: | (1) Neurorehabilitation Ward, III General Hospital in Lodz, Milionowa 14, Lodz, Poland;(2) Department of Chemistry and Clinical Biochemistry, Medical University of Lodz, Pl. Hallera 1, Lodz, Poland;(3) Department of General Biochemistry, University of Lodz, Banacha 12/16, Lodz, Poland |
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Abstract: | Oxidative stress leads to lipid peroxidation and may contribute to the pathogenesis of lesions in multiple sclerosis (MS),
an autoimmune disease characterized by inflammatory as well as degenerative phenomena. Isoprostanes are prostaglandin-like
compounds which are formed by free radical catalysed peroxidation of arachidonic acid esterified in membrane phospholipids.
They are a new class of sensitive specific markers for in vivo lipid peroxidation. In this study 26 patients (15 females and
11 males; mean age 48.2 ± 15.2 year; mean disease duration 10.0 ± 6.5 year) with secondary progressive MS (SPMS) and 12 healthy
controls were enrolled. In patients with multiple sclerosis the lipid peroxidation as the level of urine isoprostanes and
the level of thiobarbituric acid reactive species (TBARS) in plasma were estimated. Moreover, we estimated the total antioxidative
status (TAS) in plasma. It was found that the urine isoprostanes level was over 6-fold elevated in patients with SPMS than
in control (P < 0.001). In SPMS patients TBARS level was also statistically higher than in controls (P < 0.01). However, we did not observed any difference of TAS level in serum between SPMS patients and controls (P > 0.05). In patients with SPMS the lipid peroxidation and oxidative stress measured as the increased level of isoprostanes
was observed. Thus, we suggest that the level of isoprostanes may be used as non-invasive marker for a determination of oxidative
stress what in turn, together with clinical symptoms, may determine an specific antioxidative therapy in SPMS patients. |
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