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Radiation target analysis of glycoproteins
Authors:E S Kempner  J H Miller  M J McCreery
Institution:1. National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 USA;2. Division of Cutaneous Hazards, Letterman Army Institute of Research, The Presidio of San Francisco, San Francisco, California 94129 USA;1. Physical Science and Technology College, Zhengzhou University, Zhengzhou 450001, China;2. College of Science, Henan University of Technology, Zhengzhou 450001, China;1. Molecular Biology Division, Bhabha Atomic Research Centre, Mumbai 400085, India;2. Molecular Biology Research Laboratory, Department of Zoology, SPPU, Pune 411007, India;3. Bioinformatics Centre, SPPU, Pune 411007, India;4. Homi Bhabha National Institute, Training School Complex, Anushakti Nagar, Mumbai 400094, India;1. Department of Physics, Behbahan Khatam Alanbia University of Technology, Behbahan 6361647189, Iran;2. Department of Physics, School of Sciences, Shiraz University, Shiraz 71454, Iran;3. Department of Physics, Isfahan University of Technology, Isfahan 8415683111, Iran;4. Department of Mathematics, Behbahan Khatam Alanbia University of Technology, Behbahan 6361647189, Iran
Abstract:The radiation sensitivity of glycoproteins is shown to depend only on the protein portion of the molecule. An artificially created glycoprotein containing glucose-6-phosphate dehydrogenase observes this rule as well as natural enzymes and receptors containing from 2 to 50% carbohydrate. No exceptions have been found. Radiation damage to carbohydrates occurs close to the site of the primary ionization, with little spread of damage into attached polypeptides.
Keywords:
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