肝脏细胞在生物活性物质代谢调控中的协作作用

肝实质细胞和非实质细胞是肝脏功能的物质和结构基础.肝实质细胞是肝脏的主要细胞类型之一,承担和执行肝脏代谢、信号转导、解毒和稳态调节等多种功能.而非实质细胞也必不可少,主要包括星型细胞、肝窦内皮细胞、枯否细胞、自然杀伤细胞和隐窝细胞等,具有物质和信号转运、吞噬、抗原提呈、免疫耐受等功能.目前,有关肝脏生理功能和病理机制的研究主要集中在组织、细胞和差异分子的水平,单细胞的生理和病理功能研究也越来越深入,而肝脏细胞协作的研究比较少,系统性总结也鲜有报道.本文从肝脏细胞相互协作的角度,对肝脏的生理功能及病理机制进行探讨,为全面了解肝细胞生理功能及肝脏疾病的致病机理提供参考.

Cooperation of Liver Cells in the Metabolism Regulation of Bioactive Substances

Hepatocyte and nonparenchymal cells are the key foundation of liver structure and function. Hepatocyte is one of the main liver cell types, involved in large physiological processes, such as material metabolism, detoxication, and homeostasis. On the other hand, the nonparenchymal cells, including hepatic stellate cell, liver sinusoidal endothelial cell, kupffer cell, natural killer cell and pit cell, perform the material transportation, phagocytose, antigen presentation and immune tolerance. However, at present there is few research on cell cooperation between hepatocyte and the nonparenchymal cells in liver physiological and pathological process. This paper aims to comprehensively summarize the interaction between different kinds of liver cells both in health and disease conditions to provide references for further studies of the specific molecular mechanism of liver diseases.