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Some biochemical observations on gluconeogenesis from propionate in hepatocytes isolated from normal and biotin-deficients rats |
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| Authors: | A Djabal M Mangeot B Cherruau A Lemonnier |
| Abstract: | Propionate and pyruvate added to isolated normal and biotin-deficient adult rat hepatocytes increase the production of glucose. This production decreases about 30% on biotin deficiency. Malonate inhibits gluconeogenesis from propionate showing the metabolic transformation of propionyl-CoA via the Krebs cycle. Neither glucagon nor dibutyryl-cyclic AMP significantly stimulate gluconeogenesis. |
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