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Phospholipid methylation affects immunoglobulin E-mediated histamine and arachidonic acid release in rat leukemia basophils |
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| Authors: | F T Crews Y Morita F Hirata J Axelrod R P Siraganian |
| Affiliation: | 1. Section on Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20205, USA;2. Clinical Immunology Section, Laboratory of Microbiology and Immunology, National Institute of Dental Research, Bethesda, Maryland 20205, USA |
| Abstract: | Antigenic stimulation of rat basophilic leukemia cells sensitized with immunoglobulin E causes the release of histamine as well as arachidonic acid and its metabolites. The release of these substances is preceded by an increase in phospholipid methylation. Inhibition of phospholipid methylation is correlated to the inhibition of histamine release. Inhibition of methylation also reduces arachidonate release. Phospholipid methylation appears to be associated with both histamine secretion and the release of arachidonate and its metabolites. |
| Keywords: | IgE immunoglobulin E EDTA ethylenediaminetetraacetic acid |
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