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生命科学研究的又一个里程碑——记2003年度诺贝尔化学奖
引用本文:陈联万,李姗姗,汲娟娟. 生命科学研究的又一个里程碑——记2003年度诺贝尔化学奖[J]. 生物化学与生物物理进展, 2003, 30(6): 833-837
作者姓名:陈联万  李姗姗  汲娟娟
作者单位:中国科学院生物物理研究所脑与认知科学研究中心,中国科学院视觉信息加工重点实验室,北京,100101
摘    要:瑞典皇家科学院宣布 ,美国的两位科学家Agre和MacKinnon ,因他们在细胞膜物质转运通道蛋白质研究方面的重要发现分享 2 0 0 3年度诺贝尔化学奖 .Agre发现了水通道 (waterchannel) ,并且解释了水通道对水分子的选择性通透等重要特性 ;MacKinnon确立了K 离子通道的高分辨率的三维结构 ,并且详细地阐明了其离子选择性等功能机制 .两位科学家把他们对科学研究前沿领域的高度敏感性与科学的方法论紧密结合在一起 .他们从化学基础研究出发 ,为生命科学前沿领域后基因组的研究作出了卓越贡献

关 键 词:2003年度诺贝尔化学奖  水通道  K 通道  分子结构  信号转导
收稿时间:2003-11-12
修稿时间:2003-11-12

Another Milestone of The Life Sciences Research--The Nobel Prize in Chemistry 2003
CHEN Lian-Wan,LI Shan-Shan and JI Juan-Juan. Another Milestone of The Life Sciences Research--The Nobel Prize in Chemistry 2003[J]. Progress In Biochemistry and Biophysics, 2003, 30(6): 833-837
Authors:CHEN Lian-Wan  LI Shan-Shan  JI Juan-Juan
Affiliation:Laborary of Visual Information Processing, Centre for Brain and Cognitive Sciences, Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China;Laborary of Visual Information Processing, Centre for Brain and Cognitive Sciences, Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China;Laborary of Visual Information Processing, Centre for Brain and Cognitive Sciences, Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China
Abstract:The Royal Swedish Academy of Sciences announced that T he Nobel Prize in Chemistry for 2003 is shared between two USA scientists in honor of their discoveries concerning channels in cell membranes. Agre discovered water channels of the cell membrane, and clarified important properties such as the selectivity for water molecules of the water channels. MacKinnon clarified the 3D structure of the K channels with high resolution, and elucidated its functional mechanisms such as ion selectivity in detail. The two scientists utilized their high sensitivity for the top scientific research and methodology. They started their work from the basic research of biochemistry, and made excellent contribution to the post genome study, which is the top area in the field of life sciences.
Keywords:The Nobel Prize in Chemistry 2003   water channel   K channel   structure   signal transduction
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