Graphene oxide supported rhombic dodecahedral Cu2O nanocrystals for the detection of carcinoembryonic antigen |
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| Authors: | Taotao Feng Xiaoyu ChenXiuwen Qiao Zhao SunHaining Wang Yu Qi Chenglin Hong |
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| Affiliation: | School of Chemistry and Chemical Engineering, Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Production and Construction Corps, Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi 832003, People''s Republic of China |
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| Abstract: | In this work, a simple electrochemical immunosensor was developed for the detection of carcinoembryonic antigen (CEA) based on rhombic dodecahedral Cu2O nanocrystals–graphene oxide–gold nanoparticles (rCu2O–GO–AuNPs). GO as the template and surfactant resulting in rCu2O exhibit improved rhombic dodecahedral structure uniformity and excellent electrochemical performance. Moreover, GO was found to be able to effectively improve the long stability of rCu2O on the electrode response. Under optimal conditions, the immunosensor showed a low limit of detection (0.004 ng ml−1) and a large linear range (0.01–120 ng ml−1). This work presents a potential alternative for the diagnostic applications of GO-supported special morphology materials in biomedicine and biosensors. |
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| Keywords: | Graphene oxide Rhombic dodecahedral Cu2O nanocrystals Gold nanoparticles Immunosensor Carcinoembryonic antigen |
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