Enzyme promiscuity in the hormone-sensitive lipase family of proteins |
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Authors: | Giuseppe Manco Luigia Merone Elena Porzio Yan Feng Luigi Mandrich |
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Affiliation: | Istituto di Biochimica delle Proteine, Consiglio Nazionale delle Ricerche, Via. P. Castellino 111, 80131, Naples, Italy. g.manco@ibp.cnr.it |
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Abstract: | The number of enzymes endowed with the capacity to catalyse other reactions than the main, physiological one, a feature that has been called promiscuity, is increasing at a fast pace. Promiscuity is a highly pervasive phenomenon that is present at each level of life complexity. For enzymes, promiscuity encompasses interesting aspects related to their physiological role, evolution and biotechnological applications. Herein, at first we will describe some general aspects of enzyme promiscuity and then we will report some examples from the α/β hydrolase superfamily of proteins, with particular emphasis to the hormone-sensitive lipase family. |
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